The shooting happened in the area near East 10th Street and North Rural Street just before 7:45 a.m.
Police say the victim, 34-year-old Martel Thomas, was found dead in an ally and that it appears he may have been shot in the head.
People walking in the ally actually found the victim.
Neighbors reported hearing gunshots around 5:30 a.m.
Anyone with information is urged to contact Crime Stoppers at 317-262-8477.