According to deputies, drugs and alcohol may be factors in the crash.
INDOT reports the center lane of eastbound Interstate 465 was closed near Interstate 69 because of the crash.
Fishers Police tweeted there were injuries at the scene of the crash, but the severity of those injuries wasn’t immediately clear.
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Students and faculty returning to Purdue University this fall will notice a number of enhancements to public safety on campus.
Chopper 8 flew over a number of Central Indiana counties that were flooded after heavy rains on Friday.
Chopper 8 flew over the business fire near State Road 3 and State Road 18.
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Heavy rains that moved through Central Indiana on Thursday and Friday left a number of counties flooded.
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For a complete list of roadways in the county that are closed click on the story.
The crash happened on I-69 northbound, just south of the 264 exit, which is State Road 18.